SEARCHED TERM
Probable tuberculous meningitis (TBM)
DEFINITION
Diagnosed when: 1) a patient presented with clinical features of meningitis and 2) suggestive cerebrospinal fluid laboratory findings of TBM, plus 3) one or more of the following i) chest radiograph findings consistent with pulmonary TB, ii) an extra-meningeal specimen positive for AFB, iii) other evidence of extra-meningeal TB (e.g. abdominal ultrasound features) or iv) brain computed tomography (CT) evidence of TBM.
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SOURCE DEFINITION
Total score of ≥12 when neuroimaging available or total score of ≥10 when neuroimaging unavailable. At least 2 points should either come from CSF or cerebral imaging criteria.
OTHER DEFINITIONS
Diagnosed when: 1) a patient presented with clinical features of meningitis and 2) suggestive CSF findings of TBM (total white cell count .5 cells6106/L, protein .0.45 g/L and glucose 2.2 mmol/L), plus 3) one or more of the following i) chest radiograph findings consistent with pulmonary TB, ii) an extra-meningeal specimen positive for AFB, iii) other evidence of extra-meningeal TB (e.g. abdominal ultrasound features) or iv) brain computed tomography (CT) evidence of TBM including one or more of the following: basal meningeal enhancement, hydrocephalus or infarctions.
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