SEARCHED TERM
Purified protein derivative (PPD), tuberculin
DEFINITION
Material used in diagnostic tests to measure immune reactivity to past or present M. tuberculosis infection. PPD is a purified tuberculin preparation that was developed in the 1930s and derived from old tuberculin. It is administered as part of a tuberculin skin test (TST) that is given as an intradermal injection of 0.1 ml containing 5 TU (Mantoux method) and read 48–72 hours later.
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SOURCE DEFINITION
Material used in diagnostic tests for infection with M. tuberculosis. PPD is a purified tuberculin preparation that was developed in the 1930s and derived from old tuberculin. In the United States, it is administered as part of a TST that is given as an intradermal injection of 0.1 ml containing 5 TU (Mantoux method) and read 48–72 hours later. It also was used in the older version of QFT-G.
OTHER DEFINITIONS
Material used in diagnostic tests for M. tuberculosis infection. In the United States, PPD solution (5 tuberculin units per 0.1 mL) is approved for administration as an intradermal injection as a diagnostic aid for M. tuberculosis infection (latent infection or TB disease). PPD tuberculin also was one of the antigens in the first-generation QuantiFERON-TB test
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