Symptomatic patients with compatible clinical and/or radiology and/or histology for TB and a positive microbiological test (confirmed TB), or with compatible clinical and/or radiology and/or histology for TB and started TB treatment (clinical TB)

Caused by Mycobacterium tuberculosis. The bacteria can attack any part of the body, but they typically attack the lungs. TB disease is diagnosed by isolation of M. tuberculosis in a culture. TB disease of the lungs or larynx can be transmitted when a person with the disease coughs, sings, laughs, speaks, or breathes. TB disease might be infectious

Illness in which TB bacteria multiply and attack a part of the body, usually the lungs. The symptoms of active TB disease include weakness, weight loss, fever, loss of appetite and night sweats. Other symptoms of TB disease depend on where in the body the bacteria are growing. If TB disease is in the lungs (pulmonary TB), the symptoms may include a bad cough, pain in the chest and coughing up blood. A person with pulmonary TB disease may be infectious and spread TB bacteria to others

Occurs in someone with TB infection when the bacteria inside the body start to multiply and become numerous enough to damage one or more organs of the body. This damage causes clinical symptoms and signs and is referred to as “tuberculosis” which implies active disease. Persons with TB disease are considered infectious and may spread TB bacteria to others

Determined by finding anatomic changes caused by advancing infection (e.g., shadows from infiltrates on a chest radiograph) or by noting symptoms (e.g., malaise, feverishness, or cough), and typically by both. Positive culture results for M. tuberculosis complex typically are interpreted as both an indication of TB disease and its confirmation, but infecting organisms can be obtained from patients who have no other evidence of disease

Condition caused by infection with a member of the M. tuberculosis complex that has progressed to causing clinical (manifesting symptoms or signs) or subclinical (early stage of disease in which signs or symptoms are not present, but other indications of disease activity are present) illness. The bacteria can attack any part of the body, but disease is most commonly found in the lungs (pulmonary TB). Pulmonary TB disease can be infectious, whereas extrapulmonary disease (occurring at a body site outside the lungs) is not infectious, except in rare circumstances

Illness that occurs in someone infected with Mycobacterium tuberculosis and is characterized by clinical signs and symptoms, with or without laboratory or radiographic evidence