SEARCHED TERM
Cross-resistance
DEFINITION
Resistance to multiple anti-tuberculosis agents caused by a single genetic change (or multiple changes, in case the given resistance mechanisms require several genetic alterations).
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SOURCE DEFINITION
Resistance to multiple anti-tuberculosis agents caused by a single genetic change (or multiple changes, in case the given resistance mechanisms requires several genetic alterations), although in practice such mutations may not be known.
OTHER DEFINITIONS
Mutations that confer resistance to one anti-TB drug may also confer resistance to some or all of the members of the same drug family, and less commonly, to members of different drug families
Resistance to one anti-TB medicine conferred to some or all members of the same family of medicines or, less commonly, to members of different families of medicines, e.g. kanamycin and amikacin have high cross-resistance – that is, if a strain is resistant to one of these medicines, it is also resistant to the other
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