SEARCHED TERM
Paradoxical tuberculosis-associated IRIS (immune reconstitution inflammatory syndrome)
DEFINITION
Recurrent, new, or worsening symptoms or signs of tuberculosis following initiation of antiretroviral therapy (ART) in people living with HIV, diagnosed with tuberculosis, and started on anti-tuberculosis treatment before ART. These signs or symptoms typically occur within the first few weeks and up to 3 months after ART is initiated.
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SOURCE DEFINITION
(for use in resource-limited settings) Patients that have been diagnosed with active tuberculosis before initiation of Antiretroviral Therapy (ART), and have typically been responding to antituberculosis treatment. Following initiation of ART, IRIS presents as the development of recurrent, new, or worsening symptoms or signs of tuberculosis, such as fever, return of cough, or lymph node enlargement, or recurrent, new, or deteriorating radiological manifestations. These symptoms typically occur within the first few weeks and up to 3 months after ART is initiated, restarted, or changed because of treatment failure.
OTHER DEFINITIONS
(in resource-limited settings) Individual diagnosed to have TB before initiation of HAART who typically responded to anti-TB treatment but developed paradoxical worsening of symptoms within three months of initiation of HAART
Immunopathological reaction occurring in 4–54 % patients who start antiretroviral therapy (ART) while on treatment for tuberculosis (TB)
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