SEARCHED TERM

Pre-extensively drug resistant (XDR) tuberculosis

RELATED TAGS Drug resistance

DEFINITION

Tuberculosis caused by M. tuberculosis strains that fulfil the definition of multidrug-/rifampicin-resistant (MDR/RR-TB) and that are also resistant to any fluoroquinolone.

RELATED TERMS

Drug-resistant tuberculosis (DR-TB)Extensively drug-resistant tuberculosis (XDR-TB)

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SOURCE DEFINITION

TB caused by Mycobacterium tuberculosis (M. tuberculosis) strains that fulfil the definition of MDR/RR-TB and that are also resistant to any fluoroquinolone.

From: WHO
Year: 2022
Source: WHO consolidated guidelines on tuberculosis: module 4: treatment: drug-susceptible tuberculosis treatment

OTHER DEFINITIONS

TERM 1

MDR-TB with resistance to either a fluoroquinolone, or at least 1 of 3 injectable second-line TB drugs, but not both

From: Scientific article (J Pediatric Infect Dis Soc.)
Year: 2013
TERM 2

Resistance to any FQ or to at least one of the three SLIs (amikacin, capreomycin and kanamycin), in addition to multidrug resistance. NB: Although this use of the definition for pre-XDR-TB is widespread, it is not officially recognised

From: The Union
Year: 2018
TERM 3

Identify MDR-TB with additional resistance to either one but not both these classes of drugs

From: CDC
Year: 2019
TERM 4

Strains with MDR-TB and additional resistance to fluoroquinolones only

From: WHO
Year: 2018

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