SEARCHED TERM
Sputum culture conversion
DEFINITION
Two consecutive negative cultures from sputa collected at least 25 days apart.
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SOURCE DEFINITION
Two consecutive negative cultures from sputa collected at least 25 days apart (as well as all intermediate cultures), and this culture negativity was not followed by a confirmed positive Mycobacteria Growth Indicator Tube (MGIT) culture (or a single positive sputum result after the subject completed the trial), and the subject did not discontinue up to the time point being analyzed.
OTHER DEFINITIONS
Culture considered to have converted to negative when two consecutive cultures, taken at least 30 days apart, are found to be negative. In such a case, the specimen collection date of the first negative culture is used as the date of conversion
Two sets of consecutive negative smears and cultures, from samples collected at least 30 days apart
At least two consecutive negative sputum cultures taken between 7 to 30 days apart at a trial-defined time point after at least one initial positive sputum. One missing or contaminated culture may occur between the two negative cultures. Inability to produce sputum even with induction is considered to be a negative result. Sputum culture conversion is said to occur at the time of the first negative culture
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