SEARCHED TERM
Tuberculous meningitis (TBM)
DEFINITION
Tuberculosis of the meninges. There are several TBM case definitions (definite, probable, and possible tuberculosis meningitis) which depend on the presence of a) signs or symptoms of meningitis, b) bacteriological confirmation, c) cerebral imaging features , or d) composite clinical score.
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SOURCE DEFINITION
Patients should fulfill criterion A or B: A) Clinical entry criteria( Symptoms and signs of meningitis including one or more of the following: headache, irritability, vomiting, fever, neck stiff ness, convulsions, focal neurological defi cits, altered consciousness, or lethargy) plus one or more of the following: acid-fast bacilli seen in the CSF; Mycobacterium tuberculosis cultured from the CSF; or a CSF positive commercial nucleic acid amplifi cation test. B) Acid-fast bacilli seen in the context of histological changes consistent with tuberculosis in the brain or spinal cord with suggestive symptoms or signs and CSF changes, or visible meningitis (on autopsy).
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