TB Case definition
Unmasking tuberculosis-associated IRIS
Type of immune reconstitution inflammatory syndrome that occurs when a patient is not receiving treatment for tuberculosis when ART is initiated and then presents with tuberculosis within 3 months of starting ART. One of the following criteria must be met: Heightened intensity of clinical manifestations, presentation with pulmonary tuberculosis that is complicated by respiratory failure due to adult respiratory distress syndrome, or those who present with a marked systemic inflammatory syndrome related to tuberculosis.
Tuberculous meningitis (TBM)
Tuberculosis of the meninges. There are several TBM case definitions (definite, probable, and possible tuberculosis meningitis) which depend on the presence of a) signs or symptoms of meningitis, b) bacteriological confirmation, c) cerebral imaging features , or d) composite clinical score.
Other previously treated patients
People with tuberculosis who have previously been treated for tuberculosis but whose outcome after their most recent course of treatment is unknown or undocumented.
Probable tuberculous meningitis (TBM)
Diagnosed when: 1) a patient presented with clinical features of meningitis and 2) suggestive cerebrospinal fluid laboratory findings of TBM, plus 3) one or more of the following i) chest radiograph findings consistent with pulmonary TB, ii) an extra-meningeal specimen positive for AFB, iii) other evidence of extra-meningeal TB (e.g. abdominal ultrasound features) or iv) brain computed tomography (CT) evidence of TBM.
Prolonged paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)
TB-IRIS symptoms lasting >90 days.
Persons with unknown previous tuberculosis treatment history
Persons who do not fit into any of the categories of relapse, treatment after failure, treatment after loss to follow up, and other previously treated.
Laboratory confirmed tuberculosis meningitis (TBM)
Tuberculosis diagnosed when 1) AFB were seen in cerebrospinal fluid (CSF), 2) AFB or M. tuberculosis is cultured from CSF or 3) M. tuberculosis is detected by PCR from CSF.
Laboratory confirmed tuberculosis
Synonym of bacteriologically confirmed tuberculosis.
HIV associated tuberculosis
Tuberculosis occurring in a person living with HIV.
Confirmed case of multi-drug resistant tuberculosis (MDR-TB)
Person with a positive culture for M. tuberculosis which has been confirmed through a drug-susceptibility test to be resistant in vitro to at least isoniazid and rifampicin.
